Five Cups of Coffee Per Day can be Lethal, Says Study

It is the first study in the world to look at higher doses of coffee, rather than the equivalent of one or two cups, and it found that five coffees doubled the fat around organs in the abdomen - a type of fat that causes deadly conditions, News.com.au reported.

A compound in coffee known as Chlorogenic Acid (CGA) was thought to have health benefits, such as preventing diabetes, but a new study has found too much may cause a build up of fat and other problems.

Researchers from the WA Institute for Medical Research and the University of Western Australia were hoping to prove the cardiovascular benefits of coffee, but instead discovered it can worsen obesity and its related diseases.

The researchers found that mice given an equivalent dose of five cups of coffee for a human developed twice the amount of visceral fat - the most dangerous form of fat that collects around the organs in the abdomen.

University of WA professor Kevin Croft said that previous studies had only tested small amounts of coffee equivalent to one cup of coffee a day.

"Studies have shown that coffee consumption lowers the risk of developing Type 2 diabetes," Prof Croft said.

"With this in mind, we studied the effects of CGAs, which are very rich in coffee but also found in tea and some fruits including plums.

"The CGAs were previously known for their health benefits - increasing insulin sensitivity and reducing blood pressure and body fat accumulation," he said.

But the study proved the opposite when dosages given to mice were equivalent to five cups of coffee for a human per day, said WAIMR Assistant Professor Vance Matthews.

"We found that the equivalent of five cups of coffee a day had a tendency to increase weight gain, particularly in regards to visceral fat," Prof Matthews said.

"There was also increasing insulin resistance (which can lead to diabetes) and glucose intolerance in mice having high levels of CGA," he said.

Source-ANI

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Coffee Intake Lowers Liver Disease Risk

by Sheela Philomena on? May 19, 2013 at 9:38 AM Research News Regular coffee consumption is linked to reduced risk of primary sclerosing cholangitis (PSC), an autoimmune liver disease, say researchers.
PSC is an inflammatory disease of the bile ducts that results in inflammation and subsequent fibrosis that can lead to cirrhosis of the liver, liver failure and biliary cancer.

"While rare, PSC has extremely detrimental effects," says study author Craig Lammert, M.D., a Mayo Clinic gastroenterologist. "We''re always looking for ways to mitigate risk, and our first-time finding points to a novel environmental factor that also might help us to determine the cause of this and other devastating autoimmune diseases."

The study examined a large group of U.S. patients with PSC and primary biliary cirrhosis (PBC) and a group of healthy patients. Data showed that coffee consumption was associated with reduced risk of PSC, but not PBC. PSC patients were much likelier not to consume coffee than healthy patients were. The PSC patients also spent nearly 20 percent less of their time regularly drinking coffee than the control.

The study suggests PSC and PBC differ more than originally thought, Konstantinos Lazaridis, M.D., a Mayo Clinic hepatologist and senior study author says: "Moving forward, we can look at what this finding might tell us about the causes of these diseases and how to better treat them."

The National Institutes of Health funded part of this with a grant to principal investigator Dr. Lazaridis. The American Liver Foundation awarded Dr. Lammert a postdoctoral research fellowship.

Source-Newswise

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