Team, including doctors and scientists of the Faculty of the University of Colorado's watched medicine a fairly common variant of the mucin 5b gene, a protein that is a component of the produced by bronchial mucosa. This variant of the gene MUC5B is fairly common, pulmonary fibrosis is a disease rarely reported.
In a review of CT over 2 600 adults don't have a diagnosis of pulmonary fibrosis, the researchers found evidence of imaging of inflammation of the lungs and the scars in about 9% of the people over 50 years. In this age group, these abnormal results on computer tomography were significantly more common in people of 21 percent with the genetic variant of MUC5B.
What is important, final pulmonary fibrosis seen on CT scan has been strongly linked to the genetic variant of MUC5B. Although these anomalies do not necessarily indicate a disease that progresses, the presence of these abnormalities have been associated with more shortness of breath and cough as well as smaller lung sizes and capacity of oxygen transfer.
The results suggest that pulmonary fibrosis, which is a condition where the lung tissue becomes thickened, rigid and scarred, may be part of a syndrome less severe, much more common, but probably and could potentially be predicted on the basis of the genetic variant of MUC5B.
A paper describing the discovery was published recently in the New England Journal of Medicine.
Twenty-one authors share credit for the paper, including researchers from Brigham and Women hospital and Boston University.
Source-ANI
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